Abstract | OBJECTIVES: Some normocholesterolemic patients have coronary artery disease (CAD) in Japan. This study evaluated the clinical significance of preheparin lipoprotein lipase mass as a risk factor for normocholesterolemic patients with CAD. METHODS: RESULTS: Mild hypertriglyceridemia and low high-density lipoprotein (HDL) cholesterolemia were observed in the CAD group, and small particle size LDL and presence of midband were also common in the CAD group. Preheparin lipoprotein lipase mass level was significantly lower in the CAD group than the control group (52 +/- 18 vs 40 +/- 13 ng/ml, p = 0.005) as well as in each type of patient in the CAD group. Multiple regression analysis showed that small particle size LDL, low preheparin lipoprotein lipase mass and smoking were independent risk factors for CAD (p < 0.001, p = 0.007, p = 0.037). Low preheparin lipoprotein lipase mass concentration was observed in the small particle size LDL group and/or the midband positive group. CONCLUSIONS:
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Authors | Takashi Hitsumoto, Kunio Yoshinaga, Takeshi Sakurai, Kaneyuki Aoyagi, Jun Matsumoto, Takuo Iizuka, Michihisa Kaku, Yuko Sugiyama, Masahito Kanai, Takashi Uchi, Hirofumi Noike, Hidefumi Ohsawa, Hitoshi Watanabe, Kohji Shirai |
Journal | Journal of cardiology
(J Cardiol)
Vol. 40
Issue 1
Pg. 1-9
(Jul 2002)
ISSN: 0914-5087 [Print] Netherlands |
PMID | 12166243
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Lipids
- Heparin
- Cholesterol
- Lipoprotein Lipase
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Topics |
- Cholesterol
(blood)
- Coronary Disease
(blood, enzymology)
- Heparin
(administration & dosage)
- Humans
- Injections, Intravenous
- Insulin Resistance
- Lipids
(blood)
- Lipoprotein Lipase
(blood)
- Male
- Middle Aged
- Risk Factors
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