Autoantibodies to NOR 90/hUBF: longterm clinical and serological followup in a patient with limited systemic sclerosis suggests an antigen driven immune response.

Abstract	We describe the clinical and serological followup of a 9-year-old girl with anti-nucleolar organizing region 90/human upstream-binding factor (anti-NOR 90/hUBF) who had features of systemic sclerosis over a period of 17 years, from childhood into adulthood. We review the associations of anti-UBF autoantibodies, and provide evidence that anti-NOR 90/UBF immune response is antigen driven.
Authors	Jehan H Dagher, Ulrich Scheer, Renate Voit, Ingrid Grummt, Lilian Lonzetti, Yves Raymond, Jean-Luc Senécal
Journal	The Journal of rheumatology (J Rheumatol) Vol. 29 Issue 7 Pg. 1543-7 (Jul 2002) ISSN: 0315-162X [Print] Canada
PMID	12136917 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References	Autoantibodies Autoantigens Pol1 Transcription Initiation Complex Proteins transcription factor UBF
Topics	Autoantibodies (analysis) Autoantigens (analysis) Child Disease Progression Female Fluorescent Antibody Technique, Indirect Humans Immunoblotting Monitoring, Physiologic Nucleolus Organizer Region (immunology) Pol1 Transcription Initiation Complex Proteins (analysis, immunology) Prognosis Scleroderma, Systemic (diagnosis, immunology) Serologic Tests (methods) Severity of Illness Index Time Factors

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