Abstract | OBJECTIVES: METHODS: RESULTS: Fifty-four patients survived for more than one month, and 16 patients died within 30 days after orthotopic liver transplantation (OLT). The overall hospital survival rate was 77.1%. The hospital survival rates in the Child's A and B patients were 87.5% and 83.3%, respectively. Those rates were superior to those of the Child's C patients (P < 0.05). The outcome of patients with small hepatocellular carcinoma (HCC) was superior to that of patients with large HCC. Preoperative APACE III scores, the severity of ascites and serum creatine level had independent influence on outcome. Of the patients with fulminant HBV infection, 9 recipients survived for a follow-up period of 2 - 24 months. Treatment with lamivudine monotherapy was both well tolerated and efficacious in patients with fulminant hepatitis B. CONCLUSIONS: The results indicate that orthotopic liver transplantation could provide long-term cure and palliation for patients with HCC, and that patient selection is extremely important in predicting outcome. The results support the continued application of liver transplantation as a therapeutic modality for various end-stage liver diseases and that lamivudine is an effective and safe monotherapy in OLT for patients with HBV infection.
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Authors | Jiefu Huang, Xiaoshun He, Guihua Chen, Xiaofeng Zhu, Mingqiang Lu, Guodong Wang, Yuyang Fu, Yang Yang, Xiangdong Guan |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 115
Issue 4
Pg. 543-8
(Apr 2002)
ISSN: 0366-6999 [Print] China |
PMID | 12133294
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Adult
- Carcinoma, Hepatocellular
(mortality, surgery)
- Child
- Child, Preschool
- China
- Cholangitis, Sclerosing
(mortality, surgery)
- Female
- Follow-Up Studies
- Hepatitis B
(mortality, surgery)
- Humans
- Infant
- Liver
(pathology, surgery)
- Liver Cirrhosis
(mortality, surgery)
- Liver Neoplasms
(mortality, surgery)
- Liver Transplantation
- Male
- Middle Aged
- Schools, Medical
- Survival Rate
- Treatment Outcome
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