The effects of amlodipine on cerebral circulatory values in patients with essential hypertension.

Abstract

OBJECTIVE:

This study assessed the effects of calcium channel blocker Amlodipine on the cerebral circulation in patients with essential hypertension.

METHODS:

Cerebral circulation in 37 patients with essential hypertension and 10 healthy subjects was assessed using rheoplethysmography. In patients with essential hypertension cerebral circulation values were also re-estimated after treatment with Amlodipine (5-10 mg daily).

RESULTS:

The cerebral circulatory parameters in hypertensive patients before treatment with Amlodipine were different from those in healthy persons. Amlodipine along with the reduction in systemic blood pressure caused attenuation of cerebrovascular abnormalities: decrease in spastic signs and increase in cerebral blood supply in patients with essential hypertension.

CONCLUSION:

Amlodipine causes reduction of cerebral vascular resistance and promotes improvement in arterial blood filling in patients with essential hypertension. These changes in cerebral circulation may be secondary to the increase of cardiac output--known effect of Amlodipine.

• Authors: I G Alizade, N T Karayeva
• Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology (Anadolu Kardiyol Derg) Vol. 1 Issue 1 Pg. 14-6 (Mar 2001) ISSN: 1302-8723 [Print] Turkey
• PMID: 12122965 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Calcium Channel Blockers
• Amlodipine

Topics

• Adult
• Amlodipine (pharmacology, therapeutic use)
• Blood Pressure (drug effects)
• Calcium Channel Blockers (pharmacology, therapeutic use)
• Case-Control Studies
• Cerebral Arteries (drug effects, physiology)
• Cerebrovascular Circulation (drug effects)
• Female
• Humans
• Hypertension (drug therapy, physiopathology)
• Male
• Middle Aged
• Plethysmography, Impedance
• Treatment Outcome