[New approaches to prognosis of risk of development of gastropathies induced by nonsteroid anti-inflammatory agents].

Abstract

A pharmacological test with indomethacin is suggested for predicting the risk of NSAID-induced gastropathy. It is shown that patients with diagnoses of rheumatoid arthritis and osteoarthrosis can be divided into two groups with respect to the indomethacin test--"vulnerable" and "resistant", characterized by a high and low risk of NAIDS-induced gastropathy development, respectively. The proposed index of resistance to this disorder, together with the glutathione redox buffer test index, can be used as reliable criteria for predicting the NSAID-induced gastropathy.

• Authors: L E Ziganshina, A F Sultanova, V N Khaziakhmetova, I Kh Valeeva, A U Ziganshin
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2002 Mar-Apr Vol. 65 Issue 2 Pg. 49-52 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Novye podkhody k prognozirovaniiu riska razvitiia gastropatiĭ, indutsirovannykh nesteroidnymi protivovospalitel'nymi sredstvami.
• PMID: 12109294 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antioxidants
• Indomethacin

Topics

• Adolescent
• Adult
• Aged
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Antioxidants (metabolism)
• Humans
• Indomethacin (adverse effects)
• Lipid Peroxidation
• Male
• Middle Aged
• Rats
• Risk
• Stomach (pathology)
• Stomach Ulcer (chemically induced, diagnosis, metabolism)