[Comparative study of the anti-arrhythmic activity of cardiocyclide and nibentan in hypersympathotonia and acute myocardial ischemia].

Abstract

The antiarrhythmogenic and antifibrillar action of cardiocyclide and nibentan--class III antiarrhythmogens (according to the classification of Vaughan Williams) was experimentally studied on narcotized cats. The hypersympathotonia model was induced by a 30-sec stimulation of the left stellate cervical ganglion on the background of acute myocardial infarction. On this model of a ventricular disorder in the heart rhythm, cardiocyclide (2.4 mg/kg) and nibentan (0.2 mg/kg) exhibited pronounced antiarrhythmic activity. It is suggested that both drugs can be used under clinical conditions for the prophylaxis of sudden coronary death in patents with acute myocardial infarction.

• Authors: M B Vititnova, S A Kryzhanovskiĭ, N V Kaverina
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2002 Mar-Apr Vol. 65 Issue 2 Pg. 24-6 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'noe izuchenie antiaritmicheskoĭ aktivnosti kardiotsiklida i nibentana v usloviiakh gipersimpatotonii i ostroĭ ishemii miokarda.
• PMID: 12109286 (Publication Type: Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Benzamides
• nibentan

Topics

• Animals
• Anti-Arrhythmia Agents (therapeutic use)
• Arrhythmias, Cardiac (etiology, prevention & control)
• Autonomic Nervous System Diseases (complications, physiopathology)
• Benzamides (therapeutic use)
• Cats
• Electric Stimulation
• Electrocardiography
• Female
• Male
• Myocardial Ischemia (complications, physiopathology)
• Stellate Ganglion