Expression of Epstein-Barr virus latent membrane protein 1 and B-cell leukemia-lymphoma 2 gene in nasopharyngeal carcinoma tissues.

Abstract

Co-expression of B-cell leukemia-lymphoma 2 gene (Bcl-2) and Epstein-Barr virus latent membrane protein 1 (LMP-1) in nasopharyngeal carcinoma tissues were tested using immunohistochemical methods. Results showed that there were 32% (14/44) and 68% (30/44) LMP-1 and Bcl-2-positive cases, respectively. Among the LMP-1-positive tissues, 8 (57%) of 14 specimens were also Bcl-2-positive. The level of LMP-1 and Bcl-2 expression was associated with the clinical stages of nasopharyngeal carcinoma. Furthermore, when LMP-1- and Bcl-2-positive cases were combined, the highest positive score was found in clinical stage II as well as in the early stage (stages I and II) of nasopharyngeal carcinoma. While further studies with more cases are needed, this study suggests that co-expression of Bcl-2 and LMP-1 may be involved in the process of nasopharyngeal carcinoma aggravation.

• Authors: John Jenn-Yenn Lu, Chi-Long Chen, Tsuey-Ying Hsu, Jen-Yang Chen, Ih-Jen Su, Winston C Y Yu, Czau-Siung Yang
• Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi (J Microbiol Immunol Infect) Vol. 35 Issue 2 Pg. 136-40 (Jun 2002) ISSN: 1684-1182 [Print] England
• PMID: 12099337 (Publication Type: Comparative Study, Journal Article)

Chemical References

• EBV-associated membrane antigen, Epstein-Barr virus
• Proto-Oncogene Proteins c-bcl-2
• Viral Matrix Proteins

Topics

• Biopsy
• Carcinoma (metabolism, pathology, virology)
• Humans
• Immunohistochemistry (methods)
• In Situ Hybridization
• Mucous Membrane (pathology)
• Nasopharyngeal Neoplasms (metabolism, pathology, virology)
• Neoplasm Staging
• Proto-Oncogene Proteins c-bcl-2 (genetics, metabolism)
• Viral Matrix Proteins (genetics, metabolism)