Liver failure complicating non-alcoholic steatohepatitis following allogeneic bone marrow transplantation for Shwachman-Diamond syndrome.

Abstract

Bone marrow transplantation is potentially curative therapy for the hematologic complications associated with Shwachman-Diamond syndrome (SDS). This syndrome is, however, also associated with significant pancreatic and hepatic dysfunction, which may complicate BMT. We report a case of liver failure due to non-alcoholic steatohepatitis (NASH) following BMT for SDS. This case illustrates the need for assessing liver dysfunction pre-BMT in these patients, in addition to highlighting the potential risk posed by pre-existing steatosis for the development of rapidly progressive hepatic failure following transplantation.

• Authors: D S Ritchie, P W Angus, P S Bhathal, A P Grigg
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 29 Issue 11 Pg. 931-3 (Jun 2002) ISSN: 0268-3369 [Print] England
• PMID: 12080360 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Bone Marrow Transplantation (adverse effects)
• Contraindications
• Exocrine Pancreatic Insufficiency (complications, therapy)
• Fatal Outcome
• Fatty Liver (complications, etiology, pathology)
• Female
• Hepatitis (complications, etiology, pathology)
• Humans
• Liver Failure (etiology, pathology)
• Myelodysplastic Syndromes (complications, therapy)
• Transplantation, Homologous (adverse effects)