Abstract | BACKGROUND: Mean platelet volume (MPV) has been shown to be an independent risk factor for myocardial infarction in the general population. METHODS: RESULTS: Mean platelet volume in hemodialysis patients was 8.22 +/- 0.06 fl. As compared with hemodialysis patients with a MPV <7.168 fl (the lower quintile limit), significantly more hemodialysis patients with a MPV >9.172 fl (the upper quintile limit) had CHD (odds ratio, 1.29; 95% confidence interval, 1.02-1.64). In a stepwise multiple logistic regression analysis MPV appeared to be an independent factor of CHD together with age, smoking, predialysis systolic blood pressure and serum triglyceride concentration. In a stepwise multiple linear regression model, MPV significantly depended on platelet count, volume of ultrafiltrate removed in one hemodialysis session, white blood cell count, treatment with beta blockers, heart rate, serum sodium and serum potassium concentrations. Additional measurements in 30 patients showed that MPV after a single hemodialysis session was not significantly different compared to predialysis values. CONCLUSION: From the present study it is concluded that MPV may be associated with CHD in hemodialysis patients.
|
Authors | Bernard F Henning, Walter Zidek, Bertolt Linder, Martin Tepel |
Journal | Kidney & blood pressure research
(Kidney Blood Press Res)
Vol. 25
Issue 2
Pg. 103-8
( 2002)
ISSN: 1420-4096 [Print] Switzerland |
PMID | 12077492
(Publication Type: Clinical Trial, Journal Article)
|
Copyright | Copyright 2002 S. Karger AG, Basel |
Chemical References |
- Lipids
- Phosphates
- Urea
- Potassium
|
Topics |
- Blood Platelets
(physiology)
- Blood Pressure
(physiology)
- Body Weight
(physiology)
- Coronary Disease
(blood, epidemiology, physiopathology)
- Female
- Heart Rate
(physiology)
- Humans
- Lipids
(blood)
- Male
- Middle Aged
- Phosphates
(blood)
- Potassium
(blood)
- Renal Dialysis
- Ultrafiltration
- Urea
(blood)
|