Abstract | RATIONALE: While reserpine-induced oral movements (OM), an animal model of tardive dyskinesia, are more persistent in old than in adult rats, old animals present spontaneous OM, which are phenomenologically similar to those presented by reserpine-treated adult rats. We postulate that these OM may be the result of oxidative stress induced by both age and reserpine treatment. OBJECTIVES: METHODS: Adult (4 months of age) male Wistar rats were repeatedly treated with saline or melatonin (5 mg/kg, IP) and saline or reserpine and kept under a 12-h light/dark cycle for quantification of reserpine-induced OM as well as oxidative stress (via quantification of lipid peroxidation). To verify the effects of endogenous melatonin suppression on reserpine-induced OM, adult rats were repeatedly treated with saline or reserpine and continuously exposed to light. To verify the effects of exogenous melatonin on age-induced OM older (20 months of age) rats were long-term treated with saline or melatonin and kept under a 12-h light/dark cycle. RESULTS: CONCLUSIONS:
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Authors | V C Abílio, J A R Vera Jr, L S M Ferreira, C R M Duarte, R C Carvalho, C Grassl, C R Martins, D Torres-Leite, M Bignotto, S Tufik, R de A Ribeiro, R Frussa-Filho |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 161
Issue 4
Pg. 340-7
(Jun 2002)
ISSN: 0033-3158 [Print] Germany |
PMID | 12073160
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Age Factors
- Animals
- Corpus Striatum
(drug effects, metabolism)
- Dyskinesia, Drug-Induced
(drug therapy, metabolism, physiopathology)
- Lighting
(adverse effects)
- Lipid Peroxidation
(drug effects, physiology)
- Male
- Melatonin
(metabolism, pharmacology, therapeutic use)
- Rats
- Rats, Wistar
- Reserpine
(pharmacology)
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