Effects of two dimeric iodinated contrast media on renal medullary blood perfusion and oxygenation in dogs.

Abstract

RATIONALE AND OBJECTIVES:

To compare the effects of two iodinated contrast media, iodixanol and ioxaglate, on outer medullary blood flow (MBF) and oxygen tension (MPO(2)) in the dog kidney.

METHODS:

Iodixanol and ioxaglate were injected selectively into the renal artery (320 mgI/kg) of anesthetized Beagle dogs. MBF and MPO(2) were measured with a laser-Doppler probe and an oxygen-sensing microelectrode implanted in the outer medulla. Urine samples were collected for viscosity and osmolality measurements.

RESULTS:

Both contrast media produced a moderate decrease in MBF and MPO(2). The hypoperfusion and hypoxia lasted significantly longer with iodixanol than with ioxaglate. Theophylline, an adenosine receptor antagonist, partially prevented iodixanol-induced hypoxia. Urine viscosity was dramatically increased by iodixanol but not by ioxaglate. Urine osmolality did not differ significantly between groups.

CONCLUSION:

Iodixanol produced a more sustained medullary hypoxia than ioxaglate when injected selectively into the dog renal artery. This may lead to hypoxic cellular damage and subsequent impairment of kidney functions.

• Authors: Eric Lancelot, Jean-Marc Idée, Christine Laclédère, Robin Santus, Claire Corot
• Journal: Investigative radiology (Invest Radiol) Vol. 37 Issue 7 Pg. 368-75 (Jul 2002) ISSN: 0020-9996 [Print] United States
• PMID: 12068157 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Contrast Media
• Triiodobenzoic Acids
• Theophylline
• iodixanol
• Ioxaglic Acid

Topics

• Animals
• Contrast Media (pharmacology)
• Dogs
• Injections, Intra-Arterial
• Ioxaglic Acid (pharmacology)
• Kidney Medulla (blood supply, drug effects, metabolism)
• Male
• Oxygen Consumption (drug effects)
• Renal Artery
• Renal Circulation (drug effects)
• Theophylline (pharmacology)
• Triiodobenzoic Acids (pharmacology)
• Viscosity