NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese.
Abstract | BACKGROUND: METHODS: RESULTS: The TT genotype with null enzyme activity was found in 19.9% of the 241 noncancer gastroscopy examinees, 16.5% of the 399 first-visit outpatients, 12.7% of the esophageal cancer patients, 16.8% of the stomach cancer patients, 13.5% of the colon cancer patients, 9.7% of the rectal cancer patients, 17.7% of the lung cancer patients, 14.3% of the breast cancer patients, 16.1% of the prostate cancer patients, and 15.7% of the malignant lymphoma patients. The odds ratios ( ORs) of the genotypes were not significant for any cancers combined or for any site of cancer, except for lung cancer (OR, 0.66; 95% confidence interval [CI], 0.46-0.96 for CT relative to CC). The OR of current smoking for cancers of the esophagus and lung combined was different between the CC genotype (OR, 2.06; 95% CI, 1.06-3.98) and TT genotype (OR, 5.11; 95% CI, 1.37-19.05), although the difference was not significant. CONCLUSION: This study suggests that the CC genotype of the NQO1 C609T polymorphism is associated with the risk of lung cancer, and that the TT genotype increases the risk of smoking for cancers of the esophagus and lung.
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Authors | Nobuyuki Hamajima, Keitaro Matsuo, Hiroji Iwata, Masayuki Shinoda, Yoshitaka Yamamura, Tomoyuki Kato, Shunzo Hatooka, Tetsuya Mitsudomi, Motokazu Suyama, Yoshitoyo Kagami, Michinori Ogura, Manabu Ando, Yoshiki Sugimura, Kazuo Tajima |
Journal | International journal of clinical oncology
(Int J Clin Oncol)
Vol. 7
Issue 2
Pg. 103-8
(Apr 2002)
ISSN: 1341-9625 [Print] Japan |
PMID | 12018106
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- DNA Primers
- DNA, Neoplasm
- NAD(P)H Dehydrogenase (Quinone)
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Topics |
- Adenocarcinoma
(enzymology, genetics, pathology)
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Alleles
- Case-Control Studies
- Colorectal Neoplasms
(enzymology, genetics, pathology)
- DNA Primers
(chemistry)
- DNA, Neoplasm
(analysis)
- Female
- Genotype
- Humans
- Male
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
(genetics, metabolism)
- Odds Ratio
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Risk Factors
- Sex Factors
- Smoking
(adverse effects)
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