Efficacy and tolerability of once-daily therapy with telithromycin for 5 or 10 days for the treatment of acute maxillary sinusitis.

Abstract

BACKGROUND:

The efficacy and tolerability of oral telithromycin 800 mg once daily for 5 vs. 10 days were assessed in patients with acute maxillary sinusitis (AMS).

METHODS:

Adults (n = 341) with confirmed AMS diagnosed on clinical signs and symptoms and sinus X-ray showing total opacity or air-fluid level were randomized to receive oral telithromycin for 5 days (followed by placebo for 5 days; n = 170) or 10 days (n = 171). Causative pathogens were isolated by pretreatment sinus puncture (day 1). Clinical and bacteriologic outcomes, and safety and tolerability endpoints were assessed.

RESULTS:

Clinical cure rates post-therapy (per-protocol; days 17-21) were comparable (91.1% in the 5-day group, n = 123; 91.0% in the 10-day group, n = 133). Bacteriologic eradication rates (per-protocol) were also similar (90.7 vs. 91.3%). Both regimens were well tolerated.

CONCLUSIONS:

A 5-day course of telithromycin 800 mg once daily is an effective, well-tolerated treatment for adults with AMS, comparable to a 10-day regimen.

• Authors: K Roos, C Brunswig-Pitschner, R Kostrica, M Pietola, B Leroy, M Rangaraju, Y Boutalbi
• Journal: Chemotherapy (Chemotherapy) Vol. 48 Issue 2 Pg. 100-8 (May 2002) ISSN: 0009-3157 [Print] Switzerland
• PMID: 12011543 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
• Copyright: Copyright 2002 S. Karger AG, Basel

Chemical References

• Anti-Bacterial Agents
• Ketolides
• Macrolides
• telithromycin

Topics

• Acute Disease
• Administration, Oral
• Adolescent
• Adult
• Aged
• Anti-Bacterial Agents (administration & dosage, adverse effects, pharmacology)
• Double-Blind Method
• Drug Administration Schedule
• Female
• Humans
• Ketolides
• Macrolides
• Male
• Maxillary Sinusitis (drug therapy, pathology)
• Middle Aged
• Treatment Outcome