[Treatment of severe botulism with 3,4-diaminopyridine]].

Abstract

INTRODUCTION:

The specific treatments of botulism with serotherapy and with guanidine are of debatable efficacy. We report a case of nutritional toxin B botulism successfully treated with 3,4-diaminopyridine.

OBSERVATION:

Following a meal, a 69 year-old woman consulted for digestive disorders followed by damage to several cranial pairs, autonomous nervous system and ventilation command, motivating mechanical ventilation on tracheal intubation. Administration of symptomatic treatment with 3,4-diaminopyridine led to progressive improvement, although the diagnosis of toxin B botulism was confirmed.

COMMENTS:

Administration of 3,4-diaminopyridine, the efficacy of which had been suggested by the review of experimental literature, led to rapid and clear improvement, probably due to its potentiating effect on acetylcholine release in the neuromuscular junction.

• Authors: M Dock, A Ben Ali, A Karras, B Misset, M Garrouste-Orgeas, E Deletie, F Goldstein, J Carlet
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 31 Issue 13 Pg. 601-2 (Apr 06 2002) ISSN: 0755-4982 [Print] France
• Vernacular Title: Traitement d'un botulisme grave par la 3,4-diaminopyridine.
• PMID: 11984982 (Publication Type: Case Reports, Journal Article)

Chemical References

• rimabotulinumtoxinB
• 4-Aminopyridine
• Botulinum Toxins
• Botulinum Toxins, Type A
• Acetylcholine
• Amifampridine

Topics

• 4-Aminopyridine (administration & dosage, adverse effects, analogs & derivatives)
• Acetylcholine (metabolism)
• Aged
• Amifampridine
• Botulinum Toxins
• Botulinum Toxins, Type A
• Botulism (diagnosis, drug therapy, transmission)
• Female
• Foodborne Diseases (diagnosis, drug therapy)
• Humans
• Neuromuscular Junction (drug effects)
• Treatment Outcome