GAP-43 expression and pathological changes of temporal infarction in rats and effects of batroxobin.

Abstract

UNLABELLED:

To study the changes of the expression of growth-associated protein-43 (GAP-43) and pathology in temporal infarction of rats photochemically induced and the effects of batroxobin.

METHODS:

Immunohistochemical technique and hematoxylin-eosin stain was used to show the changes of the expression of GAP-43 and pathology.

RESULTS:

In infarction group, GAP-43 expression was markedly increased on the infarction and surrounding tissues at 24 h cerebral infarction. The expression reached peak level at 72 h after cerebral infarction and was decreased at 7 d after cerebral infarction. However, in batroxobin-treated group, GAP-43 expression was increased and the pathological changes were much slight as compared with infarction group.

CONCLUSION:

The expression of GAP-43 increases in infarction of temporal neocortex and batroxobin promotes the expression of GAP-43 and ameliorates the pathological changes in infarction of temporal neocortex.

• Authors: Weiping Wu, Xingzhi Guan, Xiaoshu Zhang, Peigen Kuang
• Journal: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan (J Tradit Chin Med) Vol. 22 Issue 1 Pg. 42-6 (Mar 2002) ISSN: 0255-2922 [Print] China
• PMID: 11977521 (Publication Type: Journal Article)

Chemical References

• Fibrinolytic Agents
• GAP-43 Protein
• Batroxobin

Topics

• Animals
• Batroxobin (pharmacology)
• Brain Infarction (metabolism, pathology)
• Fibrinolytic Agents (pharmacology)
• GAP-43 Protein (biosynthesis, genetics)
• Male
• Neocortex (pathology)
• Random Allocation
• Rats
• Rats, Wistar
• Temporal Lobe (pathology)