Effects of fluoxetine on the 5-HT1A receptor and recovery of cognitive function after traumatic brain injury in rats.

Abstract

OBJECTIVE:

This study examined the effects of chronic administration of fluoxetine, a selective serotonin reuptake inhibitor, on cognitive performance and 5-HT1A receptor immunoreactivity following traumatic brain injury.

DESIGN:

Rats received a moderate severity of lateral fluid percussive injury or sham injury 24 hr after surgical preparation. Fluoxetine or vehicle was administered chronically on postinjury days 1-15. Motor performance and Morris water maze performance were assessed on postinjury days 1-5 and 11-15, respectively.

RESULTS:

Results indicated that chronic fluoxetine treatment did not affect motor or maze performance. Injured groups showed significantly higher 5-HT1A receptor immunoreactivity on postinjury day 15 than sham-injured rats, and fluoxetine treatment did not alter 5-HT1A receptor immunoreactivity.

CONCLUSIONS:

These results indicate that chronic postinjury fluoxetine administration did not influence the recovery of motor or Morris water maze performance following lateral fluid percussive injury. They also indicate that injury-induced changes in the 5-HT1A receptor may contribute to traumatic brain injury-induced cognitive deficits.

• Authors: Margaret S Wilson, Robert J Hamm
• Journal: American journal of physical medicine & rehabilitation (Am J Phys Med Rehabil) Vol. 81 Issue 5 Pg. 364-72 (May 2002) ISSN: 0894-9115 [Print] United States
• PMID: 11964577 (Publication Type: Journal Article)

Chemical References

• Receptors, Serotonin
• Receptors, Serotonin, 5-HT1
• Serotonin Uptake Inhibitors
• Fluoxetine

Topics

• Animals
• Brain Injuries (drug therapy, physiopathology)
• Cognition (drug effects)
• Disease Models, Animal
• Fluoxetine (pharmacology, therapeutic use)
• Male
• Maze Learning (drug effects)
• Postural Balance (drug effects)
• Rats
• Rats, Sprague-Dawley
• Receptors, Serotonin (drug effects, metabolism)
• Receptors, Serotonin, 5-HT1
• Recovery of Function (drug effects)
• Selective Serotonin Reuptake Inhibitors (pharmacology, therapeutic use)