Cyclooxygenase inhibition: between the devil and the deep blue sea.

Abstract	Non-steroidal anti-inflammatory drugs (NSAIDs) account for more reports of drug related toxicity than any other class of drugs. Their most widely recognised adverse effects are on the gastrointestinal tract. They cause acute erosions and chronic ulcers that result in hospitalisation and death because of ulcer bleeding and perforation. Between them, aspirin and non-aspirin NSAIDs may account for more than half of all episodes of ulcer bleeding and perforation.
Authors	C J Hawkey
Journal	Gut (Gut) Vol. 50 Suppl 3 Pg. III25-30 (May 2002) ISSN: 0017-5749 [Print] England
PMID	11953329 (Publication Type: Journal Article, Review)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Isoenzymes Lactones Membrane Proteins Proton Pump Inhibitors Pyrazoles Sulfonamides Sulfones Thiazines Thiazoles rofecoxib Cyclooxygenase 2 PTGS2 protein, human Prostaglandin-Endoperoxide Synthases Celecoxib Meloxicam
Topics	Anti-Inflammatory Agents, Non-Steroidal (adverse effects) Arthritis (drug therapy) Celecoxib Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors (adverse effects) Gastroscopy Humans Isoenzymes (antagonists & inhibitors) Kidney (drug effects) Lactones (adverse effects) Meloxicam Membrane Proteins Myocardial Infarction (chemically induced) Prostaglandin-Endoperoxide Synthases Proton Pump Inhibitors Pyrazoles Randomized Controlled Trials as Topic Stomach Ulcer (chemically induced) Sulfonamides (adverse effects) Sulfones Thiazines (adverse effects) Thiazoles (adverse effects)

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