[Study on improvement of liver cirrhosis and liver function in hepatolenticular degeneration patients treated with integrated Traditional and Western medicine].

Abstract

OBJECTIVE:

To observe the effects of sodium dimercaptosulphonate (DMPS) plus Gandou tablet, DMPS and calcium disodium ethylene diaminotetraacetate (EDTA) on improving liver cirrhosis and liver function of hepatolenticular degeneration (HLD) patients.

METHODS:

One hundred and forty-six HLD patients were divided into A, B, C three groups, and treated with DMPS plus Gandou tablet, DMPS and EDTA respectively, the therapeutic course was 8 weeks for three groups. The ultrasonography of liver, electrophoresis of serum protein and excretion of urinary copper were observed.

RESULTS:

The ultrasonography of liver was improved in all groups, the rate of improvement of group A was 54.0%, B was 44.0% and C was 39.1%. The amounts of serum albumin in A and B groups increased (P < 0.01, P < 0.05), and gamma-globulin decreased in all groups (P < 0.05). The excretion of urinary copper increased obviously in all groups (P < 0.01), and A, B groups increased more than that of C group (P < 0.05).

CONCLUSIONS:

The de-copper therapy could improve liver cirrhosis and liver function. The effect of DMPS plus Gandou tablet was better than that of DMPS and EDTA.

• Authors: M Hong, G Wang, R Yang
• Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine (Zhongguo Zhong Xi Yi Jie He Za Zhi) Vol. 20 Issue 12 Pg. 890-2 (Dec 2000) ISSN: 1003-5370 [Print] China
• PMID: 11938856 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Unithiol

Topics

• Adolescent
• Adult
• Drug Therapy, Combination
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Hepatolenticular Degeneration (complications, drug therapy, physiopathology)
• Humans
• Liver (physiopathology)
• Liver Cirrhosis (drug therapy, etiology, physiopathology)
• Male
• Unithiol (therapeutic use)