Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.

Abstract

From a marine-derived strain of the fungus Emericella variecolor, varitriol (1), varioxirane (2), dihydroterrein (3), and varixanthone (4), besides the known mold metabolites ergosterol, terrein, shamixanthone, and tajixanthone hydrate, were identified. The chemical structures of 1-4 were established by means of spectroscopic techniques and some chemical transformations. In the NCI's 60-cell panel, varitriol (1) displayed increased potency toward selected renal, CNS, and breast cancer cell lines. Varixanthone (4) showed antimicrobial activity.

• Authors: Joan Malmstrøm, Carsten Christophersen, Alejandro F Barrero, J Enrique Oltra, José Justicia, Antonio Rosales
• Journal: Journal of natural products (J Nat Prod) Vol. 65 Issue 3 Pg. 364-7 (Mar 2002) ISSN: 0163-3864 [Print] United States
• PMID: 11908979 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Antifungal Agents
• Benzyl Alcohols
• Cyclopentanes
• Furans
• Xanthenes
• Xanthones
• dihydroterrein
• varioxirane
• varitriol
• varixanthone
• terrein
• xanthone
• Ergosterol

Topics

• Animals
• Antibiotics, Antineoplastic (chemistry, isolation & purification, pharmacology)
• Antifungal Agents (chemistry, isolation & purification, pharmacology)
• Benzyl Alcohols (chemistry, isolation & purification, pharmacology)
• Breast Neoplasms
• Caribbean Region
• Central Nervous System Neoplasms
• Colonic Neoplasms
• Cyclopentanes
• Drug Screening Assays, Antitumor
• Ergosterol
• Female
• Fungi (chemistry, drug effects)
• Furans (chemistry, isolation & purification, pharmacology)
• Gram-Negative Bacteria (drug effects)
• Gram-Positive Bacteria (drug effects)
• Humans
• Kidney Neoplasms
• Leukemia P388
• Lung Neoplasms
• Male
• Mice
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Porifera
• Prostatic Neoplasms
• Spectrophotometry, Ultraviolet
• Tumor Cells, Cultured (drug effects)
• Xanthenes (chemistry, isolation & purification, pharmacology)
• Xanthones