Ceftriaxone versus other cephalosporins for perioperative antibiotic prophylaxis: a meta-analysis of 43 randomized controlled trials.

Abstract

The efficacy of ceftriaxone versus other cephalosporins in the perioperative prophylaxis of surgical wound, urinary tract and respiratory tract infections was compared in a meta-analysis of randomized controlled trials published between 1986 and 1996, identified from the Medline, Embase, SIGLE, ROPU, DHSS-Data and Medikat Cologne databases. Studies were grouped by type of infection, operative specialty, wound classification, study quality and other factors, and assessed for relative risk (RR). Forty-three studies with a total of 13,482 patients met our inclusion criteria. RR for surgical wound infection (n = 13,303 patients) was 30% lower in the ceftriaxone versus control groups [98.3% confidence interval (CI): 0.55-0.89; p = 0.0002]. In urinary tract infections (n = 8,865 patients), the primary analysis of all studies showed marked superiority for ceftriaxone (RR: 0.53; 98.3% CI: 0.43-0.67) but not in studies with CDC-defined infections (RR: 0.63; 98.3% CI: 0.36-1.12). In both types of infection, ceftriaxone was superior in contaminated operations. The data showed no advantage for ceftriaxone in other operations. In respiratory tract infections (n = 9,567 patients), there was no significant difference: the RR was 0.81 (98.3% CI: 0.61-1.09; p = 0.04).

• Authors: Eva Susanne Dietrich, Ute Bieser, Uwe Frank, Guido Schwarzer, Franz D Daschner
• Journal: Chemotherapy (Chemotherapy) Vol. 48 Issue 1 Pg. 49-56 (Mar 2002) ISSN: 0009-3157 [Print] Switzerland
• PMID: 11901257 (Publication Type: Comparative Study, Journal Article, Meta-Analysis)
• Copyright: Copyright 2002 S. Karger AG, Basel

Chemical References

• Cephalosporins
• Ceftriaxone

Topics

• Antibiotic Prophylaxis
• Ceftriaxone (therapeutic use)
• Cephalosporins (therapeutic use)
• Humans
• Odds Ratio
• Preoperative Care (methods)
• Randomized Controlled Trials as Topic
• Respiratory Tract Infections (prevention & control)
• Risk Factors
• Surgical Wound Infection (prevention & control)
• Urinary Tract Infections (prevention & control)