Oxidative metabolite of dopamine, 3,4-dihydroxyphenylacetaldehyde, induces dopamine release from PC12 cells by a Ca2+-independent mechanism.

Abstract

3,4-dihydroxyphenylacetaldehyde (DOPALD), an oxidative metabolite of dopamine (DA), induced dose-dependent DA release from pheochromocytoma (PC12) cells without affecting leakage of lactate dehydrogenase from the cells. DOPALD-induced DA release was independent of extracellular Ca2+ concentration and was not blocked by nifedipine, an L-type Ca2+ channel antagonist. These results indicated a novel intrinsic role of DOPALD in dopaminergic nerve terminals that may take part in the activation of dopamine neurons.

• Authors: Tsuneichi Hashimoto, Chihiro Yabe-Nishimura
• Journal: Brain research (Brain Res) Vol. 931 Issue 1 Pg. 96-9 (Mar 22 2002) ISSN: 0006-8993 [Print] Netherlands
• PMID: 11897094 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Channel Blockers
• 3,4-Dihydroxyphenylacetic Acid
• 3,4-dihydroxyphenylacetaldehyde
• L-Lactate Dehydrogenase
• Nifedipine
• Calcium
• Dopamine

Topics

• 3,4-Dihydroxyphenylacetic Acid (analogs & derivatives, chemical synthesis, pharmacology)
• Animals
• Calcium (physiology)
• Calcium Channel Blockers (pharmacology)
• Dopamine (metabolism)
• L-Lactate Dehydrogenase (metabolism)
• Nifedipine (pharmacology)
• Oxidation-Reduction
• PC12 Cells
• Parkinson Disease (metabolism)
• Rats