Abstract | BACKGROUND: METHODS: In a double-blind, randomized fashion, sTEA was performed with 6.6 +/- 0.5 ml of either ropivacaine, 0.75% (n = 10), or bupivacaine, 0.75% (n = 10). FEV1, vital capacity, FEV1 over vital capacity, spread of analgesia (pin prick), hand and foot skin temperatures, mean arterial pressure, heart rate, and local anesthetic plasma concentrations were measured with patients in the sitting and supine positions before and during sTEA. RESULTS: Segmental high thoracic epidural anesthesia (segmental spread C4-T8 [ bupivacaine] and C5-T9 [ ropivacaine]) significantly decreased FEV1 from 1.22 +/- 0.54 l (supine) to 1.09 +/- 0.56 l ( ropivacaine) and from 1.23 +/- 0.49 l to 1.12 +/- 0.46 l ( bupivacaine). In contrast, FEV1 over vital capacity increased from 64.6 +/- 13.5 to 68.2 +/- 14.5% ( ropivacaine) and from 62.8 +/- 12.4 to 66.5 +/- 13.6% ( bupivacaine). There was no difference between ropivacaine and bupivacaine. Skin temperatures increased significantly, whereas arterial pressure and heart rate significantly decreased indicating widespread sympathetic blockade. All 20 patients tolerated surgery well. CONCLUSIONS:
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Authors | Harald Groeben, Beatrix Schäfer, Goran Pavlakovic, Marie-Theres Silvanus, Juergen Peters |
Journal | Anesthesiology
(Anesthesiology)
Vol. 96
Issue 3
Pg. 536-41
(Mar 2002)
ISSN: 0003-3022 [Print] United States |
PMID | 11873024
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amides
- Anesthetics, Local
- Ropivacaine
- Oxygen
- Bupivacaine
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Topics |
- Adult
- Aged
- Amides
(adverse effects, pharmacokinetics)
- Anesthesia, Epidural
(adverse effects)
- Anesthetics, Local
(adverse effects, pharmacokinetics)
- Asthma
(complications, physiopathology)
- Breast
(surgery)
- Breast Neoplasms
(surgery)
- Bupivacaine
(adverse effects, pharmacokinetics)
- Double-Blind Method
- Female
- Forced Expiratory Volume
- Hemodynamics
(physiology)
- Humans
- Lung
(physiopathology)
- Male
- Middle Aged
- Oxygen
(blood)
- Posture
(physiology)
- Pulmonary Disease, Chronic Obstructive
(complications, physiopathology)
- Respiratory Function Tests
- Ropivacaine
- Skin Temperature
(physiology)
- Vital Capacity
(physiology)
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