Expression of 5-HT3 receptors in primary sensory neurons of the petrosal ganglion of adult rats.

Abstract

By using a specific antiserum, expression of the 5-HT3 receptor was examined in the petrosal ganglion (PG) of adult male rats. We found that the 5-HT3 receptors are widely distributed in the PG. This finding was confirmed by RT-PCR detection of the 5-HT3 receptor mRNA in the tissue. Unlike the distribution patterns of tyrosine hydroxylase (TH), which occurred in limited regions of PG, the 5-HT3 receptors seemed to distribute throughout the ganglion. As many TH-positive neurons in PG innervate type I cells in the carotid body, the coexistence of 5-HT3 receptor and TH in some neurons suggests that this receptor may play a role in carotid body chemoreception.

• Authors: Zun-Yi Wang, Ingegerd M Keith, E Burt Olson Jr, Edward H Vidruk, Gerald E Bisgard
• Journal: Autonomic neuroscience : basic & clinical (Auton Neurosci) Vol. 95 Issue 1-2 Pg. 121-4 (Jan 10 2002) ISSN: 1566-0702 [Print] Netherlands
• PMID: 11871776 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Catecholamines
• RNA, Messenger
• Receptors, Serotonin
• Receptors, Serotonin, 5-HT3
• Serotonin
• Tyrosine 3-Monooxygenase

Topics

• Animals
• Cardiovascular Physiological Phenomena
• Carotid Body (physiology)
• Catecholamines (biosynthesis)
• Ganglia, Sensory (cytology, metabolism)
• Glossopharyngeal Nerve (cytology, metabolism)
• Immunohistochemistry
• Male
• Neurons, Afferent (cytology, metabolism)
• RNA, Messenger (metabolism)
• Rats
• Rats, Sprague-Dawley
• Receptors, Serotonin (genetics, metabolism)
• Receptors, Serotonin, 5-HT3
• Reflex (physiology)
• Serotonin (metabolism)
• Synaptic Transmission (physiology)
• Tyrosine 3-Monooxygenase (metabolism)
• Visceral Afferents (cytology, metabolism)