Abstract |
Perfluoropolyethers (Fomblin HC products) are chemical non-reactive polymers with special physico-chemical properties that recently showed promise as protective preparations in the prevention of irritant contact dermatitis. We evaluated the efficacy of a new class of perfluoropolyethers ( perfluoropolyether phosphate, Fomblin HC/P2) in the prevention of experimentally induced cumulative irritant contact dermatitis if applied prior to irritation. A panel of 20 healthy volunteers was tested with a repetitive irritation test using 4 standard irritants ( sodium lauryl sulphate of highest purity, sodium hydroxide, lactic acid and toluene) in a randomized double-blind study. Application sites were assessed clinically and by the use of bioengineering techniques (transepidermal water loss and chromametry). Three gel preparations each containing 5% perfluoropolyether phosphate showed significant efficacy against irritation due to sodium lauryl sulphate and sodium hydroxide, while one test preparation containing 2% showed inferior benefit, indicating a dose-related effect. Preparations containing perfluoropolyether phosphates can be recommended for workplaces with water-soluble irritants. Further studies under real workplace conditions are indicated.
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Authors | S Schliemann-Willers, W Wigger-Alberti, P Elsner |
Journal | Acta dermato-venereologica
(Acta Derm Venereol)
2001 Nov-Dec
Vol. 81
Issue 6
Pg. 392-4
ISSN: 0001-5555 [Print] Sweden |
PMID | 11859938
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Fluorocarbons
- Gels
- Irritants
- Ointment Bases
- Ointments
- Lactic Acid
- Sodium Dodecyl Sulfate
- Toluene
- Sodium Hydroxide
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Topics |
- Adolescent
- Adult
- Dermatitis, Irritant
(etiology, pathology, prevention & control)
- Dermatitis, Occupational
(prevention & control)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Erythema
(chemically induced, pathology)
- Female
- Fluorocarbons
(therapeutic use)
- Gels
- Humans
- Irritants
- Lactic Acid
(adverse effects)
- Male
- Ointment Bases
- Ointments
- Sodium Dodecyl Sulfate
(adverse effects)
- Sodium Hydroxide
(adverse effects)
- Toluene
(adverse effects)
- Water Loss, Insensible
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