Abstract | BACKGROUND: METHOD: The effects of the supplementation of vitamin B6 to antipsychotic treatment on positive and negative symptoms in 15 schizophrenic and schizoaffective patients (DSM-IV criteria) were examined in a double-blind, placebo-controlled, crossover study spanning 9 weeks. All patients had stable psychopathology for at least 1 month before entry into the study and were maintained on treatment with their prestudy psychoactive and antiparkinsonian medications throughout the study. All patients were assessed using the Positive and Negative Syndrome Scale (PANSS) for schizophrenia on a weekly basis. Patients randomly received placebo or vitamin B6, starting at 100 mg/day in the first week and increasing to 400 mg/day in the fourth week by 100-mg increments each week. RESULTS: PANSS scores revealed no differences between vitamin B6- and placebo-treated patients in amelioration of their mental state. CONCLUSION: Further studies with larger populations and shorter duration of illness are needed to clarify the question of the possible efficacy of vitamin B6 in treatment of psychotic symptoms in schizophrenia.
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Authors | Vladimir Lerner, Chanoch Miodownik, Alexander Kaptsan, Hagit Cohen, Uri Loewenthal, Moshe Kotler |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 63
Issue 1
Pg. 54-8
(Jan 2002)
ISSN: 0160-6689 [Print] United States |
PMID | 11838627
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antipsychotic Agents
- Vitamin B 6
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Topics |
- Adult
- Aged
- Antipsychotic Agents
(therapeutic use)
- Double-Blind Method
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Psychiatric Status Rating Scales
- Psychotic Disorders
(drug therapy, psychology)
- Schizophrenia
(drug therapy)
- Schizophrenic Psychology
- Treatment Outcome
- Vitamin B 6
(therapeutic use)
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