Abstract | OBJECTIVE: METHODS: The polymorphism of DLST gene was detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) techniques in 105 patients with sporadic Alzheimer disease and 109 normal controls. RESULTS: The frequency of AT/AC genotype was found to be significantly higher in SAD patients (21%) than in controls (10%) with an odds ratio of 2.36 (P < 0.05). The frequencies of AC/AC, AT/AT genotypes and AC allele were slightly decreased in cases with SAD as compared with controls. While the frequencies of the GC/GC genotype and GC allele were slightly higher in SAD patients than in controls. However, these differences were not statistically significant (P > 0.05). CONCLUSION: The AT/AC genotype of DLST gene is associated with an increased risk for SAD.
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Authors | Q Ma, P Chan, J Yang |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 81
Issue 20
Pg. 1246-8
(Oct 25 2001)
ISSN: 0376-2491 [Print] China |
PMID | 11825528
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acyltransferases
- dihydrolipoamide succinyltransferase
|
Topics |
- Acyltransferases
(genetics)
- Aged
- Aged, 80 and over
- Alzheimer Disease
(genetics)
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic
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