Abstract | OBJECTIVES: Otic drops are commonly used not only for otitis externa, but also for otorrhea in the presence of tympanostomy tubes or tympanic membrane perforations. Many studies have demonstrated the ototoxicity of common otic preparations such as Cortisporin otic drops (Monarch Pharmaceuticals, Bristol, TN). The purpose of this study was to assess the relative ototoxicity of common otic preparations by direct exposure to isolated cochlear outer hair cells (OHCs). METHODS: OHCs from adult chinchilla cochlea were exposed to standard bathing solution (control), acetic acid, Acetasol HC (Alpharma USPD Inc., Baltimore, MD), Gentacidin (CIBA Vision Ophthalmics, Atlanta, GA), and Tobradex (Alcon, Fort Worth, TX). The cells were observed using an inverted microscope, and the images were recorded in digital still-frame and video, and analyzed on the Image Pro-Plus 3.0 program (Media Cybernetics, Silver Spring, MD). RESULTS AND CONCLUSIONS:
|
Authors | T H Jinn, P D Kim, P T Russell, C A Church, E O John, T T Jung |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 111
Issue 12
Pg. 2105-8
(Dec 2001)
ISSN: 0023-852X [Print] United States |
PMID | 11802005
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
- Drug Combinations
- Gentamicins
- hydrocortisone, neomycin, polymyxin B drug combination
- Neomycin
- Polymyxin B
- Acetic Acid
- Tobramycin
- Hydrocortisone
|
Topics |
- Acetic Acid
(toxicity)
- Administration, Topical
- Animals
- Cell Size
(drug effects)
- Cell Survival
(drug effects)
- Cells, Cultured
- Chinchilla
- Drug Combinations
- Gentamicins
(toxicity)
- Hair Cells, Auditory, Outer
(diagnostic imaging, drug effects)
- Hydrocortisone
(toxicity)
- Neomycin
(toxicity)
- Polymyxin B
(toxicity)
- Tobramycin
(toxicity)
- Ultrasonography
|