Abstract | BACKGROUND: MATERIAL/METHODS: Male Wistar rats were anaesthetised with thiopentone sodium (120 mg/kg i.p.) and instrumented for the measurements of systemic haemodynamics. Animals received lipopolysaccharide (LPS, E. coli, 6 mg/kg i.v.) or saline and were treated with either EUK-134 (0.3 or 1 mg/kg bolus injection followed by an infusion of 0.3 or 1 mg/kg/h) or its vehicle (saline). After 6 h of endotoxaemia, blood was taken to evaluate biochemical parameters of organ injury and dysfunction. All data are mean I s.e. mean of n observations. Statistical comparisons were made with a ANOVA followed by Dunnet's test for multiple comparisons. RESULTS: Endotoxaemia for 6 h caused hypotension, renal dysfunction, liver injury, skeletal-muscle injury and pancreatic injury. Treatment of rats with EUK-134 attenuated the renal dysfunction as well as the liver and skeletal muscle injury (but not the pancreatic injury) caused by endotoxin. CONCLUSIONS:
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Authors | Roberta d'Emmanuele di Villa Bianca, Nicole S Wayman, Michelle C McDonald, Aldo Pinto, Martyn A Shape, Prabal K Chatterjee, Christoph Thiemermann |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
Vol. 8
Issue 1
Pg. BR1-7
(Jan 2002)
ISSN: 1234-1010 [Print] United States |
PMID | 11796957
(Publication Type: Journal Article)
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Chemical References |
- EUK-134
- Endotoxins
- Manganese Compounds
- Organometallic Compounds
- Reactive Oxygen Species
- Salicylates
- Superoxide Dismutase
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Topics |
- Animals
- Endotoxins
(pharmacology)
- Hypotension
- Kidney
(drug effects)
- Liver
(drug effects)
- Male
- Manganese Compounds
(pharmacology)
- Muscle, Skeletal
(drug effects)
- Organometallic Compounds
(pharmacology)
- Pancreas
(drug effects)
- Rats
- Rats, Wistar
- Reactive Oxygen Species
(metabolism)
- Salicylates
(pharmacology)
- Shock, Septic
(therapy)
- Superoxide Dismutase
(chemistry, pharmacology)
- Time Factors
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