Cellular senescence and matrix metalloproteinase activity in chronic wounds. Relevance to debridement and new technologies.

Abstract

A prolonged inflammatory response may adversely affect wound closure. Delayed wound closure and extended exposure to chronic wound fluid may also affect cellular activity in a wound bed and result in cellular senescence. Prolonged inflammation and cellular senescence may adversely affect the efficacy of topically-applied biological agents, including growth factors. Appropriate wound bed preparation and debridement are necessary to improve clinical outcomes of new technologies.

• Authors: Gerit D Mulder, Jerry S Vande Berg
• Journal: Journal of the American Podiatric Medical Association (J Am Podiatr Med Assoc) Vol. 92 Issue 1 Pg. 34-7 (Jan 2002) ISSN: 8750-7315 [Print] United States
• PMID: 11796797 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review)

Chemical References

• Matrix Metalloproteinases

Topics

• Chronic Disease
• Debridement (methods)
• Humans
• Matrix Metalloproteinases (metabolism)
• Podiatry (methods)
• Prognosis
• Risk Assessment
• Risk Factors
• Wound Healing (physiology)
• Wounds and Injuries (physiopathology, therapy)