[The expression of RAR beta mRNA in rat tongue carcinogenesis].

Abstract

OBJECTIVE:

To elucidate the relationship between the expression of nuclear retinoic acid receptor beta (RAR beta) mRNA in oral carcinogenesis and squamous cell aberrant differentiation.

METHODS:

A total of 69 rat tongue carcinogenesis specimens induced by 4-nitroquinoline-1-oxide (4NQO) were detected for RAR beta mRNA by in situ hybridization.

RESULTS:

With the progress of tongue carcinogenesis and epithelium cell disdifferentiation, the expression of RAR beta mRNA was down-regulated. The positive rate of RAR beta mRNA in normal, hyperplasia, mild-moderate dysplasia, severe dysplasia, in situ carcinoma and squamous cell carcinoma was 100.0%, 87.5%, 75.0%, 72.2%, 45.5% and 18.8%, respectively.

CONCLUSIONS:

The down-regulation of RAR beta mRNA may be associated with the epithelium cell aberrant differentiation and may be an important molecular mechanism of oral carcinogenesis.

• Authors: X Liu, R He, W Chen
• Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology (Zhonghua Kou Qiang Yi Xue Za Zhi) Vol. 35 Issue 5 Pg. 343-5 (Sep 2000) ISSN: 1002-0098 [Print] China
• PMID: 11780239 (Publication Type: English Abstract, Journal Article)

Chemical References

• 4-nitroquinolone-1-oxide
• Quinolones
• RNA, Messenger
• Receptors, Retinoic Acid
• retinoic acid receptor beta
• 4-Nitroquinoline-1-oxide

Topics

• 4-Nitroquinoline-1-oxide
• Animals
• Carcinoma, Squamous Cell (metabolism)
• Disease Models, Animal
• Down-Regulation
• Quinolones
• RNA, Messenger (biosynthesis)
• Rats
• Rats, Sprague-Dawley
• Receptors, Retinoic Acid (biosynthesis, genetics)
• Tongue Neoplasms (chemically induced, metabolism)