The 5-HT2C/2B receptor agonist m-chlorophenylpiperazine (mCPP) inhibits 2-deoxy-D-glucose (2-DG)-induced hyperphagia in rats.

Abstract

Effects of the 5-HT2C2/2B receptor agonist m-chlorophenylpiperazine (mCPP) on hyperphagia elicited by 2-deoxy-D-glucose (2-DG) were investigated in rats. mCPP apparently reduced 2-DG-induced hyperphagia. Suppressive effects of mCPP on hyperphagia induced by 2-DG were inhibited by the 5-HT2A/2B/2C receptor antagonist, ritanserin, although the 5-HT2, receptor antagonist ketanserin was without effect. Thus, inhibitory effects of mCPP on 2-DG-induced hyperphagia are mediated by the 5-HT2C/2B receptor. Our results demonstrate that mCPP can inhibit the bulimia model, 2-DG-induced hyperphagia.

• Authors: Y Sugimoto, T Yoshikawa, T Noma, J Yamada
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 24 Issue 12 Pg. 1431-3 (Dec 2001) ISSN: 0918-6158 [Print] Japan
• PMID: 11767117 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antimetabolites
• Piperazines
• Receptor, Serotonin, 5-HT2B
• Receptor, Serotonin, 5-HT2C
• Receptors, Serotonin
• Serotonin Receptor Agonists
• Deoxyglucose
• 1-(3-chlorophenyl)piperazine

Topics

• Animals
• Antimetabolites (toxicity)
• Deoxyglucose (toxicity)
• Eating (drug effects, physiology)
• Hyperphagia (chemically induced, prevention & control)
• Male
• Piperazines (pharmacology, therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Receptor, Serotonin, 5-HT2B
• Receptor, Serotonin, 5-HT2C
• Receptors, Serotonin (physiology)
• Serotonin Receptor Agonists (pharmacology, therapeutic use)