Cyclic immune thrombocytopenia responsive to thrombopoietic growth factor therapy.

Abstract

We report a patient with cyclic thrombocytopenia and antiplatelet antibodies, a variant of chronic immune thrombocytopenic purpura (ITP), with a several year history of periodic fluctuation of the platelet count, megakaryocytic hyperplasia and high-titer anti-GPIb-specific antiplatelet antibodies. The patient was resistant to multiple forms of therapy but has responded to the thrombopoietic growth factor, pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF). This case suggests that some patients with classic ITP may respond to thrombopoietic growth factors.

• Authors: L Rice, J L Nichol, R McMillan, L K Roskos, M Bacile
• Journal: American journal of hematology (Am J Hematol) Vol. 68 Issue 3 Pg. 210-4 (Nov 2001) ISSN: 0361-8609 [Print] United States
• PMID: 11754405 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2001 Wiley-Liss, Inc.

Chemical References

• Autoantibodies
• Platelet Glycoprotein GPIb-IX Complex
• Recombinant Proteins
• polyethylene glycol-recombinant human megakaryocyte growth and development factor
• Polyethylene Glycols
• Thrombopoietin

Topics

• Aged
• Autoantibodies (blood)
• Female
• Humans
• Platelet Count
• Platelet Glycoprotein GPIb-IX Complex (immunology)
• Polyethylene Glycols (administration & dosage, therapeutic use)
• Purpura, Thrombocytopenic, Idiopathic (drug therapy, etiology, immunology)
• Recombinant Proteins (administration & dosage, therapeutic use)
• Thrombocytopenia (drug therapy, etiology, immunology)
• Thrombopoietin (administration & dosage, blood, deficiency, therapeutic use)