Therapeutic efficacy of intraperitoneal polymyxin B and polymyxin-like peptides alone or combined with levofloxacin in rat models of septic shock.

Abstract

The efficacy of two polymyxin-like peptides, KFFKFFKFF and IKFLKFLKFL, alone and combined with levofloxacin, was investigated in a rat model of septic shock. Rats were given an ip injection of 2 x 10(10) cfu of Escherichia coli and randomized to receive ip isotonic sodium chloride solution, 7 mg/kg levofloxacin, 1 mg/kg polymyxin B and 1 mg/kg of each polymyxin-like peptides alone or combined with 7 mg/kg levofloxacin. Polymyxins achieved a significant reduction in plasma endotoxin and tumour necrosis factor alpha (TNF-alpha) concentration. Levofloxacin significantly reduced the bacterial growth and TNF-alpha concentration. The combinations of polymyxin-like peptides and levofloxacin demonstrated the highest efficacy.

• Authors: Andrea Giacometti, Oscar Cirioni, Roberto Ghiselli, Federico Mocchegiani, Alessandra Mataloni Paggi, Fiorenza Orlando, Wojciech Kamysz, Franciszek Kasprzykowski, Zbigniew Mackiewicz, Giorgio Scalise, Vittorio Saba
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 49 Issue 1 Pg. 193-6 (Jan 2002) ISSN: 0305-7453 [Print] England
• PMID: 11751788 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Levofloxacin
• Ofloxacin
• Polymyxin B

Topics

• Animals
• Anti-Bacterial Agents (therapeutic use)
• Anti-Infective Agents (therapeutic use)
• Disease Models, Animal
• Drug Therapy, Combination (therapeutic use)
• Injections, Intraperitoneal
• Levofloxacin
• Male
• Ofloxacin (therapeutic use)
• Polymyxin B (therapeutic use)
• Rats
• Rats, Wistar
• Shock, Septic (blood, drug therapy)