Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius in mice.

Abstract

Alcoholic extract of Acanthus ilicifolius (250,500 mg/kg b wt) was found to be effective against tumour progression and carcinogen induced skin papilloma formation in mice. The extract was found to be cytotoxic towards lung fibroblast (L-929) cells in 72 h MTT assay and the concentration required for 50% cell death was 18 microg/ml. Oral administration of the extract (500 mg/kg b wt) reduced the tumour volume and administration of the same concentration increased the life span by 75% in ascites tumour (EAC cells) harbouring animals. The extract also significantly delayed the onset of dimethylbenzanthrazene DMBA/Croton oil induced skin papilloma in mice in a dose dependent manner.

• Authors: B H Babu, B S Shylesh, J Padikkala
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 79 Issue 1 Pg. 27-33 (Jan 2002) ISSN: 0378-8741 [Print] Ireland
• PMID: 11744292 (Publication Type: Journal Article)

Chemical References

• Anticarcinogenic Agents
• Carcinogens
• Plant Extracts
• 9,10-Dimethyl-1,2-benzanthracene

Topics

• 9,10-Dimethyl-1,2-benzanthracene (toxicity)
• Animals
• Anticarcinogenic Agents (therapeutic use)
• Carcinogens (toxicity)
• Male
• Mice
• Papilloma (chemically induced, drug therapy, pathology)
• Plant Extracts (therapeutic use)
• Skin Neoplasms (chemically induced, drug therapy, pathology)
• Tumor Cells, Cultured (drug effects)