High expression of the receptor tyrosine kinase Tie-1 in acute myeloid leukemia and myelodysplastic syndrome.

Abstract

The tyrosine kinase receptor Tie-1 has been shown to play a role in angiogenesis and hematopoiesis. We evaluated the level of expression and clinical significance of Tie-1 protein in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We used western blot analysis to confirm and radioimmunoassay to quantify Tie-1 protein expression in bone marrow samples obtained from untreated patients having AML (66 patients) or MDS (29 patients). Samples obtained from these patients contained significantly higher levels of Tie-1 protein than did control samples (P < 0.001). Also, Tie-1 levels were significantly higher in AML patients than MDS patients (P < 0.0001). Tie-1 levels did not correlate with complete remission or survival duration in patients having either disease. These data suggest that Tie-1 expression is increased in AML and MDS but that the level of expression does not influence the response to current therapy. The role of Tie-1 overexpression in the reported increased vascularity in the bone marrow of AML and MDS patients requires further investigation.

• Authors: S Verstovsek, E Estey, T Manshouri, M Keating, H Kantarjian, F J Giles, M Albitar
• Journal: Leukemia & lymphoma (Leuk Lymphoma) Vol. 42 Issue 3 Pg. 511-6 (Jul 2001) ISSN: 1042-8194 [Print] United States
• PMID: 11699417 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Receptors, Cell Surface
• Receptor Protein-Tyrosine Kinases
• Receptor, TIE-1
• Receptors, TIE

Topics

• Acute Disease
• Adult
• Aged
• Blotting, Western
• Bone Marrow (pathology)
• Bone Marrow Cells (cytology)
• Humans
• Leukemia, Myeloid (blood, genetics, pathology)
• Middle Aged
• Myelodysplastic Syndromes (blood, genetics, pathology)
• Radioimmunoassay
• Receptor Protein-Tyrosine Kinases (analysis, genetics)
• Receptor, TIE-1
• Receptors, Cell Surface (analysis, genetics)
• Receptors, TIE
• Reference Values