Abstract | OBJECTIVE: METHODS: RESULTS: Multivariate analysis indicated that nodal status was a significant indicator of overall survival (OS: P = 0.001). Patients with bcl-2 positive tumors had better OS than those with bcl-2 negative tumors in both univariate (P = 0.002) and multivariate analyses (P < 0.001 ). In the univariate analysis, a considerable difference in OS was observed among the expressions of bax (P = 0.077), MIB-1 proteins (P = 0.071). and OS. but the difference was not statistically significant. CONCLUSION: This study indicates that nodal status is the major prognostic tactor in patients with SCC of the larynx treated with concurrent chemoradiotherapy. These results provide useful information for predicting prognosis. Further analysis of biological factors is needed to evaluate the value as predictive markers.
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Authors | A Homma, Y Furuta, N Oridate, Y Nakano, K Yagi, T Nagahashi, S Fukuda, Y Inuyama |
Journal | Auris, nasus, larynx
(Auris Nasus Larynx)
Vol. 28 Suppl
Pg. S87-94
(May 2001)
ISSN: 0385-8146 [Print] Netherlands |
PMID | 11683351
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Apoptosis
- Biomarkers, Tumor
(analysis)
- Carcinoma, Squamous Cell
(chemistry, drug therapy, pathology, radiotherapy)
- Cell Division
- Combined Modality Therapy
- Female
- Humans
- Immunohistochemistry
- Laryngeal Neoplasms
(chemistry, drug therapy, pathology, radiotherapy)
- Male
- Middle Aged
- Time Factors
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