In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells.

Abstract

The root of Paeonia suffruticosa ANDREWS is an important Chinese crude drug used in many traditional prescriptions. 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a major component of this crude drug, was found to exhibit in vitro growth-inhibiting effect on human hepatocellular carcinoma cell line, SK-HEP-1 cells. The growth-inhibitory effect was related to the ability of PGG not only to cause a G(0)/G(1) phase arrest but also to suppress the activation of nuclear factor-kappa B. Neither apoptosis nor necrosis was observed in the cells treated with PGG. These findings suggest that PGG could be a candidate for developing a low-toxic anticancer agent.

• Authors: G S Oh, H O Pae, H Oh, S G Hong, I K Kim, K Y Chai, Y G Yun, T O Kwon, H T Chung
• Journal: Cancer letters (Cancer Lett) Vol. 174 Issue 1 Pg. 17-24 (Dec 10 2001) ISSN: 0304-3835 [Print] Ireland
• PMID: 11675148 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Hydrolyzable Tannins
• NF-kappa B
• Tannins
• pentagalloylglucose
• DNA

Topics

• Antineoplastic Agents (pharmacology)
• Apoptosis (drug effects)
• Carcinoma, Hepatocellular (pathology)
• Cell Division (drug effects)
• DNA (metabolism)
• Electrophoretic Mobility Shift Assay
• G1 Phase (drug effects)
• Humans
• Hydrolyzable Tannins
• NF-kappa B (metabolism)
• Necrosis
• Resting Phase, Cell Cycle (drug effects)
• Tannins (pharmacology)
• Tumor Cells, Cultured