Abstract | OBJECTIVE: METHODS: Using an (1)H MRS technique developed at the authors' site, the authors measured glutathione levels in a volume of interest (VOI) of 25 x 25 x 25 mm placed in structurally normal-appearing tissue in the parietooccipital region of each hemispheres in patients with and without active epilepsy, and in a age-matched control group. RESULTS: The GSH/water ratio in patients with epilepsy was significantly reduced in the parietooccipital region of both hemispheres (1.6 +/- 1.0 x 10(-5)) compared to the GSH/water ratio in healthy controls (2.4 +/- 1.1 x 10(-5)). There was no significant difference between the hemisphere with epileptogenic focus and the hemisphere without epileptogenic focus. The GSH/water ratios of the patients without active epilepsy were not different from the GSH/water ratios of patients with active epilepsy. CONCLUSION: The authors found evidence for a widespread impairment of the glutathione system in patients with epilepsy independent from seizure activity.
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Authors | S G Mueller, A H Trabesinger, P Boesiger, H G Wieser |
Journal | Neurology
(Neurology)
Vol. 57
Issue 8
Pg. 1422-7
(Oct 23 2001)
ISSN: 0028-3878 [Print] United States |
PMID | 11673583
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Protons
- Glutathione
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Topics |
- Adolescent
- Adult
- Antioxidants
(metabolism)
- Cerebral Cortex
(metabolism)
- Epilepsy, Temporal Lobe
(diagnosis, metabolism)
- Female
- Glutathione
(metabolism)
- Humans
- Magnetic Resonance Spectroscopy
- Male
- Middle Aged
- Protons
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