T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy.

Abstract

PURPOSE:

The end results after radiation therapy for T1-T2N0 glottic carcinoma vary considerably. We analyze patient-related and treatment-related parameters that may influence the likelihood of cure.

PATIENTS AND METHODS:

Five hundred nineteen patients were treated with radiation therapy and had follow-up for >or= 2 years. Three patients who were disease-free were lost to follow-up at 7 months, 21 months, and 10.5 years. No other patients were lost to follow-up.

RESULTS:

Local control rates at 5 years after radiation therapy were as follows: T1A, 94%; T1B, 93%; T2A, 80%; and T2B, 72%. Multivariate analysis of local control revealed that the following parameters significantly influenced this end point: overall treatment time (P < .0001), T stage (P = .0003), and histologic differentiation (P = .013). Patients with poorly differentiated cancers fared less well than those with better differentiated lesions. Rates of local control with laryngeal preservation at 5 years were as follows: T1A and T1B, 95%; T2A, 82%; and T2B, 76%. Cause-specific survival rates at 5 years were as follows: T1A and T1B, 98%; T2A, 95%; and T2B, 90%. One patient with a T1N0 cancer and three patients with T2N0 lesions experienced severe late radiation complications.

CONCLUSION:

Radiation therapy cures a high percentage of patients with T1-T2N0 glottic carcinomas and has a low rate of severe complications. The major treatment-related parameter that influences the likelihood of cure is overall treatment time.

• Authors: W M Mendenhall, R J Amdur, C G Morris, R W Hinerman
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (J Clin Oncol) Vol. 19 Issue 20 Pg. 4029-36 (Oct 15 2001) ISSN: 0732-183X [Print] United States
• PMID: 11600604 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Squamous Cell (pathology, radiotherapy)
• Female
• Glottis (pathology)
• Humans
• Laryngeal Neoplasms (pathology, radiotherapy)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (surgery)
• Neoplasm Staging
• Radiotherapy Dosage
• Survival Analysis