Abstract | OBJECTIVES: To investigate the role of macrophages in the pathogenesis of chronic streptococcal cell wall (SCW)-induced arthritis using liposomal clodronate. METHODS: RESULTS: SUVc significantly suppressed the development of chronic SCW-induced arthritis for up to 26 days after treatment. At this time point, ED1(+) macrophages were significantly depleted in the liver and ankle joints, although splenic macrophage numbers were not significantly different from control groups. Macrophage elimination induced a significant reduction in local levels of interleukin (IL)-1beta, IL-6, tumour necrosis factor-alpha ( TNFalpha) and matrix metalloproteinase-9 (MMP-9) from ankle joints. CONCLUSIONS: Macrophage elimination by SUVc inhibits local production of IL-1beta, IL-6, TNFalpha and MMP-9, and the pathogenesis of inflammatory arthritis.
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Authors | P J Richards, B D Williams, A S Williams |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 40
Issue 9
Pg. 978-87
(Sep 2001)
ISSN: 1462-0324 [Print] England |
PMID | 11561107
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Carriers
- Interleukin-1
- Interleukin-6
- Liposomes
- Tumor Necrosis Factor-alpha
- Clodronic Acid
- Matrix Metalloproteinase 9
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Topics |
- Animals
- Ankle Joint
(metabolism, pathology)
- Arthritis, Experimental
(drug therapy, pathology)
- Clodronic Acid
(administration & dosage, therapeutic use)
- Disease Models, Animal
- Drug Carriers
- Female
- Image Processing, Computer-Assisted
- Immunoenzyme Techniques
- Injections, Intravenous
- Interleukin-1
(metabolism)
- Interleukin-6
(metabolism)
- Liposomes
- Macrophages
(drug effects, pathology)
- Matrix Metalloproteinase 9
(metabolism)
- Rats
- Rats, Inbred Lew
- Tumor Necrosis Factor-alpha
(metabolism)
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