Epigallocatechin gallate synergy with ampicillin/sulbactam against 28 clinical isolates of methicillin-resistant Staphylococcus aureus.

Abstract

Compared with ampicillin, oxacillin, cefmetazole and imipenem, the combination of ampicillin and sulbactam at a constant ratio of 2:1 showed the greatest effect against 28 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), but MICs of ampicillin/sulbactam were still above the resistance breakpoint. When ampicillin/sulbactam was further combined with epigallocatechin gallate (EGCg, a main constituent of tea catechins), the MIC90 of ampicillin/ sulbactam was reduced to 4 mg/L, the susceptibility breakpoint. The fractional inhibitory concentration indices were between 0.19 and 0.56 in combination with 6.25 and 25 mg/L EGCg, respectively, indicating that ampicillin/sulbactam and EGCg combination may be effective against MRSA infections.

• Authors: Z Q Hu, W H Zhao, Y Hara, T Shimamura
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 48 Issue 3 Pg. 361-4 (Sep 2001) ISSN: 0305-7453 [Print] England
• PMID: 11533000 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Ampicillin
• Catechin
• epigallocatechin gallate
• Sulbactam

Topics

• Ampicillin (pharmacology)
• Anti-Bacterial Agents (pharmacology)
• Catechin (analogs & derivatives, pharmacology)
• Drug Synergism
• Humans
• Methicillin Resistance
• Microbial Sensitivity Tests
• Staphylococcus aureus (drug effects)
• Sulbactam (pharmacology)
• Time Factors