Abstract | PURPOSE: The relation between Tl-201 chloride accumulation by the tumor and its distant metastatic potential were evaluated in patients with lung adenocarcinoma and compared with the same parameters achieved using Tc-99m MIBI. METHODS: Fifty-six patients with primary lung adenocarcinoma were examined before therapy was begun. They were classified according to the radiologic findings and pathologic diagnosis into two groups: distant metastases and no distant metastases. All patients underwent dual- isotope imaging with Tl-201 chloride and Tc-99m MIBI. Regions of interest were placed over the tumor uptake (T) and contralateral normal lung tissue (N) areas on one transverse view with clearly defined lesions, and the T:N ratio and retention index were calculated. RESULTS: The early and delayed T:N ratios and retention index using Tl-201 chloride SPECT in the distant- metastases group were significantly greater (P < 0.001 to P < 0.05) than were those in the no-distant- metastases group. There was no significant correlation between the T:N ratio and retention index and distant metastatic potential using Tc-99m MIBI SPECT. CONCLUSION: Tl-201 chloride SPECT may be more effective than Tc-99m MIBI SPECT for evaluating the distant metastatic potential of primary lung adenocarcinoma.
|
Authors | Y Yamamoto, Y Nishiyama, K Fukunaga, K Satoh, M Ohkawa |
Journal | Clinical nuclear medicine
(Clin Nucl Med)
Vol. 26
Issue 9
Pg. 751-6
(Sep 2001)
ISSN: 0363-9762 [Print] United States |
PMID | 11507291
(Publication Type: Journal Article)
|
Chemical References |
- Radiopharmaceuticals
- thallium chloride
- Technetium Tc 99m Sestamibi
- Thallium
|
Topics |
- Adenocarcinoma
(diagnostic imaging, secondary)
- Adult
- Aged
- Aged, 80 and over
- Female
- Humans
- Lung Neoplasms
(diagnostic imaging)
- Male
- Middle Aged
- Radiopharmaceuticals
- Technetium Tc 99m Sestamibi
- Thallium
- Tomography, Emission-Computed, Single-Photon
|