Abstract | STUDY OBJECTIVES: DESIGN: Randomized, double-blind, double-dummy, parallel-group, multicenter trials of 12-week duration. SETTING: Outpatients in private and university-affiliated clinics. PATIENTS: Male and female patients > or = 15 years of age with a diagnosis of asthma (baseline FEV(1) of 50 to 80% of predicted) and symptomatic despite receiving inhaled corticosteroids. INTERVENTIONS: MEASUREMENTS AND RESULTS: Treatment with salmeterol powder resulted in significantly greater improvements from baseline compared with montelukast for most efficacy measurements, including morning peak expiratory flow (35.0 L/min vs 21.7 L/min; p < 0.001), percentage of symptom-free days (24% vs 16%; p < 0.001), and the percentage of rescue-free days (27% vs 20%; p = 0.002). Total supplemental albuterol use was decreased significantly more in the salmeterol group compared with the montelukast group (- 1.90 puffs per day vs - 1.66 puffs per day; p = 0.004) and nighttime awakenings per week decreased significantly more with salmeterol than with montelukast (- 1.42 vs - 1.32; p = 0.015). Patients treated with inhaled salmeterol were significantly more satisfied with their treatment regimen and how well, how fast, and how long it worked than were patients who were treated with oral montelukast. The safety profiles for the two treatments were similar. CONCLUSION:
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Authors | J E Fish, E Israel, J J Murray, A Emmett, R Boone, S W Yancey, K A Rickard |
Journal | Chest
(Chest)
Vol. 120
Issue 2
Pg. 423-30
(Aug 2001)
ISSN: 0012-3692 [Print] United States |
PMID | 11502639
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Acetates
- Adrenal Cortex Hormones
- Adrenergic beta-Agonists
- Anti-Asthmatic Agents
- Bronchodilator Agents
- Cyclopropanes
- Powders
- Quinolines
- Sulfides
- Salmeterol Xinafoate
- montelukast
- Albuterol
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Topics |
- Acetates
(administration & dosage)
- Administration, Inhalation
- Adolescent
- Adrenal Cortex Hormones
(administration & dosage)
- Adrenergic beta-Agonists
(administration & dosage)
- Adult
- Aged
- Aged, 80 and over
- Albuterol
(administration & dosage, analogs & derivatives)
- Anti-Asthmatic Agents
(administration & dosage)
- Asthma
(drug therapy)
- Bronchodilator Agents
(administration & dosage)
- Cyclopropanes
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Powders
- Quinolines
(administration & dosage)
- Salmeterol Xinafoate
- Sulfides
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