A case of glassy cell carcinoma of the uterine cervix effectively responding to chemotherapy with paclitaxel and carboplatin.

Abstract

Glassy cell carcinoma (GCC) of the uterine cervix is a highly malignant tumor and has a poor prognosis. As yet, no effective systemic chemotherapy to this tumor has been reported. Here we describe a case of recurrent GCC that responded to paclitaxel and carboplatin combination treatment. The patient, a 32-year-old woman, with clinical staging FIGO IB1 disease had a radical hysterectomy and postoperative radiotherapy. Three months after initial treatment, she had a relapse as peritoneal dissemination, which was confirmed in the second surgery (adnectomy) and which did not respond to platinum-based conventional chemotherapy (cisplatin, adriamycin, cyclophosphamide and carboplatin, etoposide). The recurrent peritoneal tumors responded well to paclitaxel and carboplatin combination treatment. An elevated serum concentration of carcinoembryonic antigen (672 ng/ml) was reduced to 14.4 ng/ml by six such courses. Peritoneal histopathology confirmed a complete response in the third surgery (ileostomy) for adhesive ileus by the radiotherapy. This is the first report of effective systemic chemotherapy with paclitaxel and carboplatin to recurrent GCC of the uterine cervix.

• Authors: Y Hirashima, H Kobayashi, T Nishiguchi, K Miura, N Kanayama
• Journal: Anti-cancer drugs (Anticancer Drugs) Vol. 12 Issue 7 Pg. 627-30 (Aug 2001) ISSN: 0959-4973 [Print] England
• PMID: 11487720 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carcinoembryonic Antigen
• Carboplatin
• Paclitaxel

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carboplatin (administration & dosage)
• Carcinoembryonic Antigen (metabolism)
• Carcinoma, Squamous Cell (drug therapy, pathology)
• Female
• Humans
• Neoplasm Recurrence, Local
• Paclitaxel (administration & dosage)
• Treatment Outcome
• Uterine Cervical Neoplasms (drug therapy, pathology)