The presence of hemoglobin S and C Harlem in an individual in the United States.

Abstract

The first reported case of hemoglobin S and C Harlem in an individual is described. The patient, a 35-yr-old female, had numerous crises during adolescence and early adulthood, but these occurred more infrequently as she grew older. Chemical evidence is presented for the characterization of both variant hemoglobins. The clinical course of this individual with Hb S in combination with Hb C Harlem appears to be similar to that for persons with sickle cell anemia.

• Authors: W Moo-Penn, K Bechtel, D Jue, M S Chan, G Hopkins, N J Schneider, J Wright, R M Schmidt
• Journal: Blood (Blood) Vol. 46 Issue 3 Pg. 363-7 (Sep 1975) ISSN: 0006-4971 [Print] United States
• PMID: 1148394 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Hemoglobin, Sickle
• Hemoglobins, Abnormal
• Peptide Fragments
• Hemoglobin C
• Trypsin
• Cyanogen Bromide

Topics

• Adult
• Amino Acids (analysis)
• Anemia, Sickle Cell (blood)
• Autoanalysis
• Chromatography, DEAE-Cellulose
• Cyanogen Bromide
• Female
• Hemoglobin C (analysis)
• Hemoglobin, Sickle (analysis)
• Hemoglobins, Abnormal
• Humans
• New York City
• Peptide Fragments
• Trypsin