Response to HBV vaccine in relation to vaccine dose and anti-HCV positivity: a New South Wales correctional facilities' study.

Abstract

Currently, about two-thirds of inmates in NSW correctional facilities have a history of injection drug use, and about half have serological evidence of exposure to hepatitis C virus. The introduction of an accelerated hepatitis B vaccination program (0-1-2 months) in 1998, using a 20 microg/dose vaccine was necessitated by the need to vaccinate eligible inmates in this high-risk environment characterised by rapid client mobility. Since 1999, both 10 and 20 microg doses of vaccine were introduced. We found that sero-response rates were not significantly influenced by HCV antibody status, but were significantly lower in cohorts of inmates vaccinated with the 10 microg dose of vaccine.

• Authors: N Awofeso, M Levy, S Harper, M Jones, M Hayes, J Douglas, M Fisher, D Folpp
• Journal: Vaccine (Vaccine) Vol. 19 Issue 30 Pg. 4245-8 (Jul 20 2001) ISSN: 0264-410X [Print] Netherlands
• PMID: 11457551 (Publication Type: Journal Article)

Chemical References

• Hepatitis B Vaccines
• Hepatitis C Antibodies

Topics

• Dose-Response Relationship, Immunologic
• Hepatitis B Vaccines (immunology)
• Hepatitis C Antibodies (blood)
• Humans
• Vaccination