In vitro activity of ABT-773 versus macrolides and quinolones against resistant respiratory tract pathogens.

Abstract

ABT-773, a novel ketolide, was compared to erythromycin, azithromycin, clarithromycin, ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin, gatifloxacin, and gemifloxacin against antibiotic-resistant strains recently isolated from patients with respiratory tract infections. MICs were determined by agar dilution using standard NCCLS methodology. ABT-773 (MIC(90) 0.06 mg/L) was more active than the macrolides (MIC(90) > or = 2 mg/L) and fluoroquinolones (MIC(90) > or = 0.5 mg/L) against penicillin-resistant Streptococcus pneumoniae. The fluoroquinolones were the most active agents tested against beta-lactamase-positive Haemophilus influenzae (MIC(90) < or = 0.01-0.06 mg/L), against which ABT-773 (MIC(90) 4 mg/L) was comparable to azithromycin and two- and four-fold more active than erythromycin and clarithromycin, respectively. Against beta-lactamase positive Moraxella catarrhalis, the activity of ABT-773 (MIC(90) 0.06 mg/L) was comparable to gemifloxacin, trovafloxacin, levofloxacin, and ciprofloxacin (MIC(90) 0.03-0.06 mg/L) and 4- to eightfold greater than that of clarithromycin, gatifloxacin, and erythromycin. These data suggest ABT-773 could be a valuable compound for the treatment of respiratory tract infections, including those resistant to usual oral therapy.

• Authors: J Dubois, C St -Pierre
• Journal: Diagnostic microbiology and infectious disease (Diagn Microbiol Infect Dis) 2001 May-Jun Vol. 40 Issue 1-2 Pg. 35-40 ISSN: 0732-8893 [Print] United States
• PMID: 11448561 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Anti-Infective Agents
• Fluoroquinolones
• Ketolides
• Erythromycin
• cethromycin

Topics

• Anti-Bacterial Agents (pharmacology)
• Anti-Infective Agents (pharmacology)
• Bacteria (drug effects)
• Bacterial Infections (microbiology)
• Drug Resistance, Microbial
• Erythromycin (analogs & derivatives, pharmacology)
• Fluoroquinolones
• Haemophilus influenzae (drug effects)
• Humans
• Ketolides
• Microbial Sensitivity Tests
• Moraxella catarrhalis (drug effects)
• Respiratory Tract Infections (microbiology)
• Streptococcus pneumoniae (drug effects)
• Streptococcus pyogenes (drug effects)