Abstract |
Studies to determine the total number of circulating lymphocytes and their morphologic transformation in the presence of phytohemagglutinin and pokeweed mitogen were carried out in 156 women: 81 who currently had an ovarian cancer or who had had it in the past; 54 normal women; and 21 patients with malignant diseases. The latter two groups served as controls. The total number of circulating lymphocytes is an important cosideration, as there is a significant decrease of lymphocytes in patients with ovarian cancer, a factor with great bearing on prognosis. The lymphoblastic transformation test in the presence of phytohemagglutinin and pokeweed mitogen showed not only significant changes in patients with ovarian cancer but also a correlation with survival at 6 months.
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Authors | J P Wolff, C F de Oliveira |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 45
Issue 6
Pg. 656-8
(Jun 1975)
ISSN: 0029-7844 [Print] United States |
PMID | 1143727
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Cell Transformation, Neoplastic
- Cystadenocarcinoma
(blood, immunology, mortality)
- Female
- France
- Humans
- Immunity, Cellular
- Lectins
(pharmacology)
- Leukocyte Count
- Lymphocyte Activation
- Lymphocytes
(immunology, physiology)
- Middle Aged
- Mitogens
(pharmacology)
- Ovarian Neoplasms
(blood, immunology, mortality)
- Prognosis
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