Pulmonary function changes in normal rats induced by antibody against rat IgE.

Abstract

Changes in pulmonary function, as measured by airway conductance and dynamic compliance, in normal rats have been provoked by the administration of a rabbit antisera prepared against rat IgE myeloma protein. The response is specific in that neither anti-IgG nor normal rabbit serum induced pulmonary changes. Pre-treatment with disodium cromoglycate inhibits the bronchospasm in a dose related manner. In addition, drug protection can be demonstrated with as long 1 hr pre-dosing.

• Authors: F B Casey, B E Abboa-Offei
• Journal: Clinical and experimental immunology (Clin Exp Immunol) Vol. 36 Issue 3 Pg. 473-8 (Jun 1979) ISSN: 0009-9104 [Print] England
• PMID: 114348 (Publication Type: Journal Article)

Chemical References

• Antibodies, Anti-Idiotypic
• Immunoglobulin E
• Cromolyn Sodium

Topics

• Animals
• Antibodies, Anti-Idiotypic (immunology)
• Bronchial Spasm (etiology, physiopathology, prevention & control)
• Cromolyn Sodium (therapeutic use)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Immunoglobulin E (immunology)
• Lung Compliance
• Pulmonary Ventilation
• Rats
• Time Factors