Abstract | UNLABELLED: We investigated the ability of hemoglobin-based oxygen carrying solutions (HBOCs) to alleviate fetal hypoxemia from maternal hemorrhage. Fifteen pregnant ewes (132-day gestational age) were hemorrhaged 20 mL/kg over 1 h; they were randomized to receive 20 mL/kg IV of HBOC, hetastarch (HTS), or autologous blood (BLD) (n = 5 each) over 30 min and were monitored for 2 h. Hemorrhage significantly (P < or = 0.05) decreased maternal mean blood pressure (from 98 to 48 mm Hg, median), arterial oxygen content (from 12.2 to 11.1 mL/dL), and fetal arterial oxygen content (from 8.1 to 3.9 mL/dL). Fluid replacement restored maternal blood pressure in all groups, although maternal oxygen content immediately returned to baseline only after BLD or HBOC. Maternal oxygen saturation decreased after HBOC (from 98% to 88%). Fetal oxygen content rapidly returned to baseline with either BLD (7.1 mL/dL) or HBOC (8.0 mL/dL) but was never restored with HTS (4.7 mL/dL), and, 60 min after fluid replacement, it was higher with HBOC (8.3 mL/dL) than with HTS (4.7 mL/dL). Fetal plasma-free hemoglobin did not change after HBOC. In conclusion, maternal fluid replacement with HBOC or BLD effectively restored fetal oxygenation, primarily by restoring maternal oxygen content, whereas HTS did not. IMPLICATIONS:
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Authors | P F Moon, S P Bliss, L P Posner, H N Erb, P W Nathanielsz |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 93
Issue 1
Pg. 142-50
(Jul 2001)
ISSN: 0003-2999 [Print] United States |
PMID | 11429355
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Hemoglobins
- Hydroxyethyl Starch Derivatives
- Plasma Substitutes
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Topics |
- Animals
- Blood Gas Analysis
- Cattle
- Female
- Fetal Hypoxia
(blood, drug therapy)
- Fetomaternal Transfusion
(complications)
- Fluid Therapy
- Heart Rate, Fetal
(drug effects)
- Hematocrit
- Hemodynamics
(drug effects)
- Hemoglobins
(metabolism, pharmacology)
- Hydroxyethyl Starch Derivatives
(pharmacology)
- Oxygen Consumption
(drug effects)
- Plasma Substitutes
(pharmacology)
- Pregnancy
- Sheep
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